Diabetes Mellitus is a chronic metabolic disorder in which beta cells of the pancreas cannot secrete completely, or enough insulin is required for the body to maintain the blood glucose level in the body. There are several causes of the disorder which mainly include dietary factors and lack of physical activity. Obesity and genetic factors also contribute in leading to the state of diabetes. There are various secondary complications of the disease, such as diabetic nephropathy, neuropathy, and retinopathy. This is one of the multisystem diseases which destroys multiple other systems in the body, including the cardiovascular system, nervous system. This is one of the global burdens for the modern world as the proper treatment of the disease is still unavailable. The only available for the disease is the management of the disease. Type I diabetes mellitus can only be managed by regular insulin therapy in which patients take an insulin injection as per the dosage required by the body. There are various oral hypoglycemic agents for the management of Type II diabetes mellitus. As the proper treatment of the disease is undiscovered, still multiple approaches are made for the treatment. There are various other herbal and natural products which are used for the management of the disease, although these natural products do not have any good results. One of the approaches is to permanent reversal of the disease called reverse diabetes. The process of reverse diabetes involves the regeneration of the beta cells of the pancreas, due to which the amount of insulin required for the body can be secreted, and the blood glucose level can be maintained. Some of the other approaches for the reversal of diabetes include bariatric surgery, pancreas transplantation, and transplantation of islets of the pancreas.