Helicobacter is the organism widely spread in human and all known Helicobacters live in human and animal hosts especially H. pylori, where colonization occurs principally in the gastrointestinal tract and sometime responsible for serious illness such as gastritis, Peptic Ulcer Disease (PUD) and strongly associated with gastric carcinoma, MALT lymphoma. It is considered as a serious problem impairing in public health in both developing and developed countries because it colonises the gastric mucosa of about half of the world population. Although less often Non Helicobacter Pylori Helicobacter (NHPH) are also able to cause disease in humans. Helicobacter naturally infects many poultry birds, some rodent species as well as humans. Helicobacter is a zoonotic bacterium that has also been associated with certain enteric infection in humans. Helicobacter is of zoonotic importance and the animal host remains a natural reservoir for many species. And efforts for Helicobacter???s treatment is more difficult due to antibiotic resistance and patient compliance but there are various unani drugs of plants, animals and mineral origin which are being used for the treatment of Helicobacter???s infection. The aim of this review is to give a comprehensive knowledge of zoonotic potential of Helicobacters.