Abstract:

Rheumatoid arthritis is an inflammatory type of arthritis that damages and inflames joints.18 million people suffer from rheumatoid arthritis globally, and 55% in Pakistan facing this disease. Rheumatoid arthritis manifests itself between the ages of 35 and 60. Patients with rheumatoid arthritis suffer from infection, in which there is elevation of inflammatory biomarkers, CRP, erythrocyte sedimentation rate, and white blood cells. Azathioprine is an analogue of purine that has immunosuppressive qualities. It suppresses the immune system by conversion in 6-MP and blocking the enzymes that suppress or limit the availability of the adenine and guanine nucleotide, that’s lead to suppression of the immune system. As azathioprine is effective for autoimmune disease, but it has a severe effect on other organs, we must focus on nutrition. Brown seaweed is a marine macro alga having different bioactive components like fucoid etc. Brown Seaweed extract has been shown to reduce the release of inflammatory biomarkers TNF,IL-6 and IL-1 that are linked with arthritis, and seaweed reduces oxidative stress. Co-administration of azathioprine and brown seaweed will work through complementary mechanism. As azathioprine acts as an immunosuppressant, meanwhile, brown seaweed directly scavenges free radicals. This combined approach provides a comprehensive strategy for managing rheumatoid arthritis by addressing both immune system deregulation and oxidative damage, which both are both central to the disease progression.