Infertility is a reproductive system condition defined as pregnancy after at least 12 months of regular unprotected sexual intercourse. Male infertility affects 10-15% of men of childbearing age and is associated with more than 1% of infertility cases, regardless of female involvement. The causes of male infertility are diverse and difficult to classify because they are sometimes complex and associated. They may concern different stages of sperm production or sperm transport and maybe acquired or congenital. For several years, the involvement of the environment in male infertility has been the subject of much research. When a man is treated for infertility, all factors that may impact fertility must be considered, and a complete workup must be performed. The aim of our work is to describe the general profile of male infertility in patients at the in vitro fertilization center (IRIFIV) Casablanca, Morocco. This is a retrospective and descriptive study of 331 patient records seen in consultation for a couple???s marital infertility between January and October 2019. The mean age of the patients was 37.5 years. The mean duration of infertility was 5.5 years. Infertility was primary in 70.9% of cases and secondary in 29.1% of cases. Clinically, varicocele was the most frequent anomaly in 65.9% of the patients. The seminogram was disturbed in 72% of cases. The primary disturbances were oligozoospermia in 40.20 % of cases and asthenozoospermia in 37% of cases. The general pattern of infertility is polymorphous. The causes of the observed male infertility are multifactorial. Male infertility is usually caused by a quantitative and qualitative sperm abnormality. The improvement of infertility management must involve new research avenues, mainly genetic and immunological, to identify the usually hidden causes of infertility.