INTRODUCTION: Uqr (infertility) is defined as a failure to conceive within one or more years of regular unprotected coitus. It is estimated that nearly 10-15% of couples are infertile in India. Among them, the male is directly responsible in about 30-40%, the female in about 40-55% and both are responsible in about 10% cases. The remaining 10% is unexplained. Some of the lifestyle factors leading to infertility are increasing marital age, rising alcohol and tobacco consumption and obesity, smoking, and some clinical factors like ovarian and tubal dysfunction, vaginal and cervical factors, biochemical changes in cervical secretions, and the presence of anti-sperm antibody which leads to cervical hostility may be implicated as an immunological factor of infertility. In classical text books of unani, infertility is defined as Uqr (banjhpan), and it occurs due to congenital defect of the uterus & ovaries, furbahi (obesity), su’i mizaj-e-Rahem, su’I mizaj-e-madde manwia, fasad e mani, which leads to faulty production of ovum as well as difficulty in conception. According to Unani physicians, the basic principle of Unani treatment is the correction of abnormal temperament, use of mukhawwi e rahem advia. Some effective unani drugs help induce ovulation such as; asgand, tukhm e shivlingi, tukhm e shambhalu,inderjushireen, Zafran, burada e dandaane feel, resha e bargad, joz bua etc. Phittakri biriyan, roghan e chambeli and poste anaar are also helpful as local applicants. Some compound unani formulations are habbe hamal, majune moine hamal ambari, dawa-ul-misk motadil, majune suparipak, etc. are also help in conception. This case study intends to give knowledge of the efficacy of Unani formulation in the management of female infertility & embracing parenthood naturally & safely without any complication & side effects. OBJECTIVES: The aim of the study was to evaluate the efficacy of Unani medicine in the management of female infertility. METHODOLOGY: A single clinical case study of infertility was conducted in the Department of Amraz e Niswan wa Qabalat Govt Nizamia Tibbi College and Hospital, Hyderabad. An infertile couple was selected, Age of the patient was 26 years old and anxious to conceive, and willing to participate in the study. Treatment was planned to give Oral unani compound medicine like Habbe Hamal, Majoone Moine Hamal, and Dawaul Misk Motadil. Which are Muqavvi Rahem and muallid e mani as well as help in conception and some unani formulation was made which consists of Roghan e chambeli, zafran, Sufoof e inderjau Shireen which are used as a humool for 5 days. RESULT: the patient has shown a good response with unani medicine and conceived within 2 months of treatment without any side effects. CONCLUSION: The study proved the efficacy of unani medicine in managing female infertility without any side effects.