Nanomaterial can be defined as the ???material with any external dimension in the nanoscale or having internal structure or surface structure in the nanoscale???, with nanoscale defined as the ???length range approximately from 1 nm to 100 nm???. Over a period of time a number of innovative therapies have been emerged in the field of wound healing. Nanostructured systems have been used to improve wound healing at different stages. The drug itself may be formulated at a nanoscale such that it can function as its own ???carrier??? or nanomaterials may be used as drug delivery vehicles. If we observe the latest advancements on innovative nano-based organic and inorganic materials we find that these novel drug delivery systems possess high stability, large surface area and tunable compositions and have demonstrated their wound-healing properties using in vitro and in vivo models. The nanotechnology-based platforms are an exciting emerging field with many applications on wound healing in the last decade. Numerous investigators have designed several inorganic and metal nanoparticles including magnetic, silica silver, nano graphene oxide scaffolds, copper and gold terbium oxide, cerium and titanium dioxide, etc. and demonstrated their wound healing properties. Hence nanomaterials play a vital role in tackling with the wound healing process tremendously.