The seeds of watermelon are generally considered as agro-waste and are thrown away out in spite of its high nutritional profile and therapeutic values. Watermelons seed is and unutilized by of oil contain essential fatty acids, vitamin-E, and minerals and are rich in anti-oxidants. Since watermelon seed contains high- quality proteins, the seed meal can be used as non- conventional protein source and functional ingredients during food formulations. watermelon seeds have beneficial health impact such as growth, cardio protective effect, anti-diabetic effect, anti-obesity, anti- arthritic effect and as well as anti-ulcerogenic effect. Adequate doses of watermelon seed extracts can increase sperm count. Watermelon seed oil and watermelon seed incorporated food products are available in many countries. There is an ample scope of research to explore the bioactive ingredients responsible for the positive health benefits of these and the use of value-added products from watermelon seeds.