Alzheimer’s disease is the most common form of dementia; it is a syndrome in which there is deterioration in thinking, memory, behavior and the ability to perform everyday activities. Brain cell connections and the cells themselves degenerate and die which eventually destroy the memory and other important mental functions. According to WHO, 50 million people around the world have dementia and there are nearly 10 million new cases every year. Genetic factors play an important role and about 15% of cases are familial age is the strongest risk factor. In the Unani system of medicine there is no direct reference to this disorder but Alzheimer’s disease is almost associated with Nisyan or fasad-e-takhayyu’l or dimag ki kharabi. Etiology according to unani system of medicine is that it is due to viscid phlegm (Balgam Ghaleez) and excess moistness (Rutoobath) in brain.Unani system of medicine is endeavoured with enormous single and compound drugs with least side effects which can enhance the condition. Unani drugs with actions like Muhaffizat, muslihaat, Muqqawiat,Moadilath and Munish-ehararath- e-ghariziya are preferred.