Antibiotics are potent medicines that fight next to certain infections also can prevent further infections and save lives when used properly in therapeutic dose. They both prevent bacteria from reproducing and destroy them. Antibiotics are one of the most significant discoveries in the field of medicine. The purpose of the current study was to know the prescribing pattern of antibiotics in admitted patients in a tertiary care hospital in Bangalore. The objective of the study was to figure out the average number of antibiotics prescribed per prescription to identify the indication for which the antibiotics were frequently prescribed. There was A Cross sectional, observational study with 228 patients who were prescribed antibiotics, were included in this research with age between 15 to more than 65 years. The study was carried out for period of 6 months inpatient department from August 2019 to January 2020. The study reveals that out of 228 patients with antibiotics in the prescription is 81% , 49% of them are prescribed with at least one antibiotic and distribution of Broad spectrum antibiotics accounted for 61% and most of antibiotics prescribed are in 23% general medicine department and commonly given route is oral 60% i.e., cephalosporins 26% and penicillin’s 19.6%. This study concluded that appropriate and sustainable interventions should be implemented that will ease the threat of antibiotic resistance. This emphasizes the need to provide training about antibiotic prescription patterns for rational use and avoid Polypharmacy across healthcare settings to improve patient care development and provide better quality of life.