Preparation And Evaluation Of Bifonazole Hydrogel For Topical Application
G. B Kiran Kumar* , Prakash Goudanavar , Ankit Acharya , B. Ramesh
DOI : 10.46890/SL.2022.v03i02.001
Abstract
The present work aimed to prepare and evaluate the topical hydrogel formulation of an anti-fungal drug Bifonazole. Total 10 batches of Bifonazole (1% w/w) hydrogel formulations were prepared by using two different polymers i.e., HPMC K100M and chitosan. SLS, PEG 400 and Oleic acid were used as permeation enhancers. Methyl paraben and propyl paraben were used as preservative. Prepared hydrogel was evaluated for pH, viscosity, rheology, spreadability, drug content, in-vitro diffusion studies, ex-vivo skin permeation studies, release kinetics studies and short-term stability studies. All batches of gel formulations showed uniform homogeneity and spreadability. The physical appearance of the gel formulations was white translucent in nature. pH of the gel formulation was suitable for topical application. Formulation batches containing combination of polymers showed significantly increased viscosity when compared to control formulation. The highest drug permeability was achieved when permeation enhancers were used in the formulation. Release profile was increased with increase in permeation enhancer concentration. Highest percentage of drug release and permeability was achieved from formulation F8. The in-vitro release profile of drug from all gel formulations followed zero order kinetics and showed Super case II transport mechanism. Short term stability studies showed that physicochemically stable throughout the stability period. In conclusion, permeation enhancerbased hydrogel formulation of Bifonazole was successfully formulated to improve the drug release and skin permeability.
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The present work aimed to prepare and evaluate the topical hydrogel formulation of an anti-fungal drug Bifonazole. Total 10 batches of Bifonazole (1% w/w) hydrogel formulations were prepared by using two different polymers i.e., HPMC K100M and chitosan. SLS, PEG 400 and Oleic acid were used as permeation enhancers. Methyl paraben and propyl paraben were used as preservative. Prepared hydrogel was evaluated for pH, viscosity, rheology, spreadability, drug content, in-vitro diffusion studies, ex-vivo skin permeation studies, release kinetics studies and short-term stability studies. All batches of gel formulations showed uniform homogeneity and spreadability. The physical appearance of the gel formulations was white translucent in nature. pH of the gel formulation was suitable for topical application. Formulation batches containing combination of polymers showed significantly increased viscosity when compared to control formulation. The highest drug permeability was achieved when permeation enhancers were used in the formulation. Release profile was increased with increase in permeation enhancer concentration. Highest percentage of drug release and permeability was achieved from formulation F8. The in-vitro release profile of drug from all gel formulations followed zero order kinetics and showed Super case II transport mechanism. Short term stability studies showed that physicochemically stable throughout the stability period. In conclusion, permeation enhancerbased hydrogel formulation of Bifonazole was successfully formulated to improve the drug release and skin permeability.