Standardization and Pharmacological Investigation of Different Extracts of Brassica juncea Seed for Wound Healing Activity
Sanjay Kumar* , Ranjit Singh
DOI : 10.46890/SL.2022.v03i01.005
Abstract
Majority of the global population from developing countries relies on herbal medicines for cure of diseases. The ability to sense the environment and sustain physico-chemical and thermal homeostasis is dependent on our skin. Healing process is the mechanism of repairing the skin and other soft tissues after an injury. Brassica juncea has traditionally been used for its antibacterial and antioxidant properties. The current research was intended to investigate the wound-healing behaviour of B. juncea in order to generate comprehensive scientific evidence. Excision and incision wound models were used to test the wound-healing effectiveness of aqueous, ethanolic, and petroleum ether extracts of B. juncea. Physical analyses of the crude compound were carried out along with the quantitative analysis of phenolics and flavonoids. The rate of wound contraction, the duration of full epithelialization, and the tensile strength of the incision wound were investigated. The three extracts from B. juncea seeds were noted to heal the wound, as evidenced by a reduction in epithelialization time, an improvement in wound contraction rate, and increased skin-breaking ability. The ethanolic and aqueous extracts have characteristics that make them effective in wound- healing action as compared to a placebo control, according to the current report.
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Majority of the global population from developing countries relies on herbal medicines for cure of diseases. The ability to sense the environment and sustain physico-chemical and thermal homeostasis is dependent on our skin. Healing process is the mechanism of repairing the skin and other soft tissues after an injury. Brassica juncea has traditionally been used for its antibacterial and antioxidant properties. The current research was intended to investigate the wound-healing behaviour of B. juncea in order to generate comprehensive scientific evidence. Excision and incision wound models were used to test the wound-healing effectiveness of aqueous, ethanolic, and petroleum ether extracts of B. juncea. Physical analyses of the crude compound were carried out along with the quantitative analysis of phenolics and flavonoids. The rate of wound contraction, the duration of full epithelialization, and the tensile strength of the incision wound were investigated. The three extracts from B. juncea seeds were noted to heal the wound, as evidenced by a reduction in epithelialization time, an improvement in wound contraction rate, and increased skin-breaking ability. The ethanolic and aqueous extracts have characteristics that make them effective in wound- healing action as compared to a placebo control, according to the current report.